Synonyms: CCX 354 | CCX-354 | CCX-354-C
Compound class:
Synthetic organic
Comment: CCX354 is an orally active CCR1 antagonist that was originally developed by Chemocentryx for anti-inflammatory/immunomodulatory potential. The chemical structure is claimed as Example 16 in patent WO2008147815A1 [1]. The structure in the patent resolves to PubChem CID 25016615, which is a tautomeric representation of the claimed structure.
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Immunopharmacology Comments |
CCX354 is a failed CCR1 clinical lead anti-inflammatory/DMARD class compound, but it can be used as an experimental tool compound to study the effects of CCR1 antagonism in vitro and in vivo as determined in preclinical testing [1]. |