clopidogrel (active metabolite)

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clopidogrel (active metabolite)

Ligand id: 1772

Name: clopidogrel (active metabolite)

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	5
Hydrogen bond donors	1
Rotatable bonds	5
Topological polar surface area	105.64
Molecular weight	355.06
XLogP	2.45
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
Experimental evidence indicates that P2Y₁₂ receptors play a critical role in Th17 differentiation (in mouse models of autoimmune inflammatory diseases), and that P2Y₁₂-selective antagonists reverse Th17 differentiation and ameliorate inflammatory sequelae [2]. These findings suggest potential for P2Y₁₂ antagonists as therapeutics for autoimmune diseases.

Immunopharmacology Comments

Experimental evidence indicates that P2Y₁₂ receptors play a critical role in Th17 differentiation (in mouse models of autoimmune inflammatory diseases), and that P2Y₁₂-selective antagonists reverse Th17 differentiation and ameliorate inflammatory sequelae [2]. These findings suggest potential for P2Y₁₂ antagonists as therapeutics for autoimmune diseases.