tumour necrosis factor membrane form

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Ligands
tumour necrosis factor membrane form (Human)

GtoPdb Ligand ID: 5073

Abbreviated name: TNF membrane form

Synonyms: cachectin | necrosin | TNFα

Compound class: Endogenous peptide in human, mouse or rat

Comment: TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand.

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Immunopharmacology Comments
The approved anti-TNF biologics adalimumab and infliximab bind the soluble form of TNF- α and also inhibit the TNF-α-induced response mediated by the membrane anchored form of the cytokine [1].

Immunopharmacology Comments

The approved anti-TNF biologics adalimumab and infliximab bind the soluble form of TNF- α and also inhibit the TNF-α-induced response mediated by the membrane anchored form of the cytokine [1].