Ligand id: 6031

Name: sirolimus

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 195.43
Molecular weight 913.56
XLogP 4.32
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Disease
Disease X-Refs Comment References
Activated PI3K delta syndrome OMIM: 615513
Orphanet: ORPHA397596
Phase 1/2 clinical candidate for APDS (NCT03383380).
Graft versus host disease Approved specifically as prophylaxis of renal transplant rejection.