Ligand id: 6592

Name: A286982

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 111.74
Molecular weight 453.17
XLogP 5.51
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
The LFA-1-ICAM-1 interaction is thought to play a critical role in the inflammatory process. A286982 inhibits this interaction so can be used to investigate the physiological effects of interrupting this protein-protein interaction.