|
Synonyms: interleukin-8
Compound class:
Endogenous peptide in human, mouse or rat
Comment: The CXCL8 (IL-8) chemokine is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. It can form homodimers and heterodimers with CXCL4.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| CXCL8 bioactivity is regulated by proteolytic truncations, citrullination, and the decoy receptor DARC. It signals through two receptors - CXCR1 (IL-8 RA) and CXCR2 (IL-8 RB), and can be sequestered by binding to the protease inhibitor serpin A1 (alpha-1 antitrypsin). |
| Immunopaedia Case Studies Links |
| A case of cough, wasting and lymphadenopathy |
| A case of lymphadenopathy and night sweats |
