compound 76 [PMID: 28657314]

Ligand id: 9609

Name: compound 76 [PMID: 28657314]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 1
Rotatable bonds 16
Topological polar surface area 131.72
Molecular weight 576.25
XLogP 6.84
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Immunopharmacology Comments
IL-15 plays important roles in innate and adaptative immunity (promoting the activation and proliferation of NK, NK-T, and CD8+ T cells for example), and high expression levels are associated with inflammatory and autoimmune diseases. The development of small molecules with the potential to disrupt IL-15 receptor signalling is one of various antagonistic approaches being investigated for clinical utility. In this case researchers are attempting tp develop small molecules that inhibit protein-protein interactions at the interface of IL-15 and its receptor, specifically in this case with the IL-2Rβ component of the IL-15R complex.