Ligand id: 9625

Name: rovazolac

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 86.64
Molecular weight 452.1
XLogP 6.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
Activation of LXR is associated with inflammation, hyperproliferative and/or disordered skin barrier differentiation. Targeting LXR in inflammation is reviewed in [3].
Immunopharmacology Disease
Disease X-Refs Comment References
Atopic dermatitis Disease Ontology: DOID:3310
OMIM: 603165
Phase 2 clinical candidate for atopic dermatitis.