Synonyms: MMV1582617 | NVP-INE963
Compound class:
Synthetic organic
Comment: INE963 is a potent antimalarial compound identified by the Novartis Institute for Tropical Diseases (NITD) during an optimization study of a series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives [1]. The compound has progressed to clinical evaluation and was awarded MMV Project of the Year (2019).
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
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Guide to Malaria Pharmacology Comments |
INE963 has potential to provide a single-dose cure for uncomplicated malaria. Potential Target/Mechanism of Action: As the precise mechanism of action of INE963 is not yet known, we do not have a molecular target for this compound. |