Compound class:
Synthetic organic
Comment: E209 is a fully synthetic tetraoxane analogue with potent antimalarial activity [1].
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. |
|
References |
1. O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH et al.. (2017)
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nat Commun, 8: 15159. [PMID:28537265] |