Ligand id: 1079

Name: CGP7930

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 40.46
Molecular weight 292.24
XLogP 6.02
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prezeau L. (2004)
The heptahelical domain of GABA(B2) is activated directly by CGP7930, apositive allosteric modulator of the GABA(B) receptor.
J Biol Chem., 279: 29085-29091. [PMID:15126507]
2. Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K. (2001)
Positive allosteric modulation of native and recombinant gamma-aminobutyricacid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol(CGP7930) and its aldehyde analog CGP13501.
Mol Pharmacol., 60: 963-971. [PMID:11641424]