furazolium   Click here for help

GtoPdb Ligand ID: 10814

Synonyms: Novofur [2]
Compound class: Synthetic organic
Comment: We show the structure of the parent molecule here. The INN represents the chloride salt form (NF-963, CAS number 5118-17-2) [1]. Furazolium is a nitrofuran-derivative with antibacterial activity against Gram +ve and Gram -ve pathogens [3]. It was developed by Eaton Laboratories in the late 1960s and was tested against skin infections, but never reached clinical approval.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 101.81
Molecular weight 237.02
XLogP 1.86
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES [O-][N+](=O)c1ccc(o1)c1csc2=NCCn12
Isomeric SMILES [O-][N+](=O)c1ccc(o1)c1csc2=NCCn12
InChI InChI=1S/C9H7N3O3S/c13-12(14)8-2-1-7(15-8)6-5-16-9-10-3-4-11(6)9/h1-2,5H,3-4H2
InChI Key QWNNGDMXFGRSPJ-UHFFFAOYSA-N
References
1. Freedman R, Chamberlain RE. (1967)
In vitro antibacterial activity of furazolium chloride.
Antimicrob Agents Chemother (Bethesda), 7: 502-5. [PMID:5596181]
2. Jelenko 3rd C. (1969)
Topical control of water loss from the body surface. 3. The effects of Furazolium Chloride (Novofur) and Furacin on membrane permeability: an in vitro study.
J Surg Res, 9 (7): 415-21. [PMID:5797855]
3. Russell HE, Gutekunst DP, Chamberlain RE. (1967)
Evaluation of furazolium chloride in topical treatment of model infections in laboratory animals.
Antimicrob Agents Chemother (Bethesda), 7: 497-501. [PMID:5596180]