Synonyms: CEM-102 | CEM102 | Fucidin® | fusidate | sodium fusidate | Taksta®
fusidic acid is an approved drug (UK (1979))
Compound class:
Synthetic organic
Comment: Fusidic acid is an orally bioavailable fusidane antibacterial with activity against Gram +ve pathogens [2,4].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Craft JC, Moriarty SR, Clark K, Scott D, Degenhardt TP, Still JG, Corey GR, Das A, Fernandes P. (2011)
A randomized, double-blind phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid for the treatment of acute bacterial skin and skin structure infections. Clin Infect Dis, 52 Suppl 7: S520-6. [PMID:21546629] |
2. Jones RN, Biedenbach DJ, Roblin PM, Kohlhoff SA, Hammerschlag MR. (2010)
Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. Antimicrob Agents Chemother, 54 (10): 4518-9. [PMID:20660671] |
3. Pushkin R, Iglesias-Ussel MD, Keedy K, MacLauchlin C, Mould DR, Berkowitz R, Kreuzer S, Darouiche R, Oldach D, Fernandes P. (2016)
A Randomized Study Evaluating Oral Fusidic Acid (CEM-102) in Combination With Oral Rifampin Compared With Standard-of-Care Antibiotics for Treatment of Prosthetic Joint Infections: A Newly Identified Drug-Drug Interaction. Clin Infect Dis, 63 (12): 1599-1604. [PMID:27682068] |
4. Sahm DF, Deane J, Pillar CM, Fernandes P. (2013)
In vitro activity of CEM-102 (fusidic acid) against prevalent clones and resistant phenotypes of Staphylococcus aureus. Antimicrob Agents Chemother, 57 (9): 4535-6. [PMID:23774441] |