Synonyms: L-084 | LJC 11,084 | LJC-11,084 | LJC-11084 | Orapenem® | TBPM-PI
tebipenem pivoxil is an approved drug (Japan)
Compound class:
Synthetic organic
Comment: Tebipenem pivoxil is an orally available pivaloyloxymethyl ester prodrug of the β-lactam antibacterial tebipenem [1-2]. The ester bond is cleaved, releasing active tebipenem (PubChem CID 9800194; LJC-11036). The drug has Gram-negative activity. Tebipenem pivoxil hydrobromide (SPR994) is another formulation of the same drug.
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References |
1. Fujimoto K, Takemoto K, Hatano K, Nakai T, Terashita S, Matsumoto M, Eriguchi Y, Eguchi K, Shimizudani T, Sato K et al.. (2013)
Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrob Agents Chemother, 57 (2): 697-707. [PMID:23147735] |
2. Hazra S, Xu H, Blanchard JS. (2014)
Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry, 53 (22): 3671-8. [PMID:24846409] |
3. Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H, Shibasaki S, Kurosawa T, Tamai I. (2010)
Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Mol Pharm, 7 (5): 1747-56. [PMID:20735088] |