Compound class:
Synthetic organic
Comment: Permanently charged sodium channel blocker. This entry shows the compound without the associated bromide ion [1]. In human clinical trials as a topical gel for the treatment of pruritus (itch) associated with atopic dermatitis.
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References |
1. Ramachandran R, Thompson SK, Malkmus S, Mieda T, Lin JH, Gupta S, Yaksh TL. (2020)
Topical Application of ASN008, a Permanently Charged Sodium Channel Blocker, Shows Robust Efficacy, a Rapid Onset, and Long Duration of Action in a Mouse Model of Pruritus. J Pharmacol Exp Ther, 374 (3): 521-528. [PMID:32616515] |