Synonyms: example 18 [WO2013166396A2]
Compound class:
Synthetic organic
Comment: The chemical structure that was submitted to the WHO for the INN ipivivint leads to Samumed's patent WO2013166396A2 , as compound 18 therein [1]. Ipivivint is defined as a Wnt pathway inhibitor. Samumed have a lead candidate called SM08502 in their pipeline. SM08502 is reported to decrease Wnt signalling in tumour cells via inhibition of CDC-like kinase (CLK) activity in an article from Samumed scientists [2]. We speculate that ipivivint might be SM08502, but as of August 2020 there is no formal disclosure of SM08502's chemical structure. SM08502 is being investigated in a Phase 1 clinical trial in patients with advanced solid tumours (NCT03355066).
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References |
1. Hood J, Kumar S Kc, Wallace DM. (2014)
1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof. Patent number: WO2013166396A2. Assignee: Samumed Llc. Priority date: 04/05/2012. Publication date: 30/01/2014. |
2. Tam BY, Chiu K, Chung H, Bossard C, Nguyen JD, Creger E, Eastman BW, Mak CC, Ibanez M, Ghias A et al.. (2020)
The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models. Cancer Lett, 473: 186-197. [PMID:31560935] |