Synonyms: ONO-7475 | ONO7475
Compound class:
Synthetic organic
Comment: We obtained the chemical structure for tamnorzatinib from the WHO's proposed INN list 127 (21 July 2022). In this document it was described as a tyrosine kinase inhibitor and antineoplastic. PubChem provided the synonym ONO-7475. ONO-7475 is a clinical stage inhibitor of the TAM family receptor tyrosine kinases AXL and MER, that has been developed as a drug for the treatment of leukaemia and advanced solid tumours [1,3].
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References |
1. Okura N, Nishioka N, Yamada T, Taniguchi H, Tanimura K, Katayama Y, Yoshimura A, Watanabe S, Kikuchi T, Shiotsu S et al.. (2020)
ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Cell Lung Cancer. Clin Cancer Res, 26 (9): 2244-2256. [PMID:31953310] |
2. Post SM, Ma H, Malaney P, Zhang X, Aitken MJL, Mak PY, Ruvolo VR, Yasuhiro T, Kozaki R, Chan LE et al.. (2022)
AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3-ITD acute myeloid leukemia. Haematologica, 107 (6): 1311-1322. [PMID:34732043] |
3. Ruvolo PP, Ma H, Ruvolo VR, Zhang X, Mu H, Schober W, Hernandez I, Gallardo M, Khoury JD, Cortes J et al.. (2017)
Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms. Haematologica, 102 (12): 2048-2057. [PMID:28912176] |