olitigaltin   Click here for help

GtoPdb Ligand ID: 12148

Synonyms: GB-0139 | GB0139 | TD-139 | TD139
PDB Ligand
Compound class: Synthetic organic
Comment: Olitigaltin (GB0139) is a galectin-3 inhibitor [3] that is designed for inhalation, and is intended as a therapy for fibrotic lung conditions such as idiopathic pulmonary fibrosis (IPF) [1]. In the fibrotic setting, blocking galectin-3's biological function is predicted to combat the enhanced TGF-β receptor-mediated macrophage differentiation and myofibroblast activation that drives pathological fibrotic changes [2-4].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 12
Hydrogen bond donors 6
Rotatable bonds 8
Topological polar surface area 226.56
Molecular weight 648.18
XLogP 0.37
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC[C@H]1O[C@@H](S[C@@H]2O[C@H](CO)[C@@H]([C@@H]([C@H]2O)n2nnc(c2)c2cccc(c2)F)O)[C@@H]([C@H]([C@H]1O)n1nnc(c1)c1cccc(c1)F)O
Isomeric SMILES c1cc(cc(c1)F)c1cn(nn1)[C@H]1[C@H]([C@H](O[C@H]([C@@H]1O)S[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)n1cc(nn1)c1cc(ccc1)F)O)CO)O
InChI InChI=1S/C28H30F2N6O8S/c29-15-5-1-3-13(7-15)17-9-35(33-31-17)21-23(39)19(11-37)43-27(25(21)41)45-28-26(42)22(24(40)20(12-38)44-28)36-10-18(32-34-36)14-4-2-6-16(30)8-14/h1-10,19-28,37-42H,11-12H2/t19-,20-,21+,22+,23+,24+,25-,26-,27+,28+/m1/s1
InChI Key YGIDGBAHDZEYMT-MQFIMZJJSA-N
References
1. Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S et al.. (2021)
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Eur Respir J, 57 (5). DOI: 10.1183/13993003.02559-2020 [PMID:33214209]
2. MacKinnon AC, Farnworth SL, Hodkinson PS, Henderson NC, Atkinson KM, Leffler H, Nilsson UJ, Haslett C, Forbes SJ, Sethi T. (2008)
Regulation of alternative macrophage activation by galectin-3.
J Immunol, 180 (4): 2650-8. [PMID:18250477]
3. Mackinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J et al.. (2012)
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.
Am J Respir Crit Care Med, 185 (5): 537-46. [PMID:22095546]
4. Partridge EA, Le Roy C, Di Guglielmo GM, Pawling J, Cheung P, Granovsky M, Nabi IR, Wrana JL, Dennis JW. (2004)
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.
Science, 306 (5693): 120-4. [PMID:15459394]
5. St-Gelais J, Denavit V, Giguère D. (2020)
Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade.
Org Biomol Chem, 18 (20): 3903-3907. [PMID:32400847]