clobenpropit

Ligand id: 1223

Name: clobenpropit

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 92.36
Molecular weight 308.09
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Chen J, Liu C, Lovenberg TW. (2003)
Molecular and pharmacological characterization of the mouse histamine H3 receptor.
Eur J Pharmacol467: 57-65. [PMID:12706455]
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Genomic organization and characterization of splice variants of the human histamine H3 receptor.
Biochem J355: 279-288. [PMID:11284713]
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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.
J Pharmacol Exp Ther305: 887-896. [PMID:12606603]
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Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.
Br J Pharmacol131: 1247-1250. [PMID:11090094]
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J Pharmacol Exp Ther314: 1310-1321. [PMID:15947036]
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Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
Mol Pharmacol59: 420-426. [PMID:11179434]
7. Liu C, Wilson SJ, Kuei C, Lovenberg TW. (2001)
Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation.
J Pharmacol Exp Ther299: 121-130. [PMID:11561071]
8. Lovenberg TW, Pyati J, Chang H, Wilson SJ, Erlander MG. (2000)
Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles.
J Pharmacol Exp Ther293: 771-778. [PMID:10869375]
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The rat H3 receptor: gene organization and multiple isoforms.
Biochem Biophys Res Commun280: 75-80. [PMID:11162480]
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Cloning and characterization of a novel human histamine receptor.
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Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.
J Pharmacol Exp Ther299: 908-914. [PMID:11714875]
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Characteristics of recombinantly expressed rat and human histamine H3 receptors.
Eur J Pharmacol453: 33-41. [PMID:12393057]