impromidine

Ligand id: 1226

Name: impromidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 133.07
Molecular weight 321.17
XLogP 0.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R. (2005)
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
J Pharmacol Exp Ther, 314: 1310-1321. [PMID:15947036]
2. Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J, Pyati J, Li X, Chai W, Carruthers N, Lovenberg TW. (2001)
Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
Mol Pharmacol, 59: 420-426. [PMID:11179434]
3. Xie SX, Ghorai P, Ye QZ, Buschauer A, Seifert R. (2006)
Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines.
J Pharmacol Exp Ther, 317: 139-146. [PMID:16394198]