[125I][Sar1, D-Ala8]Ang II | Ligand page

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[¹²⁵I][Sar¹, D-Ala⁸]Ang II

[¹²⁵I][Sar¹, D-Ala⁸]Ang II

GtoPdb Ligand ID: 12299

Synonyms: ¹²⁵I-Sarcosine¹, D-Alanine⁸-Angiotensin II

Compound class: Peptide or derivative

Comment: This is a radiolabelled version of the angiotensin II analogue Sarcosine1, D-Alanine8-Ang II (TRV027) that was developed by Trevena. TRV027 is β-arrestin biased agonist of angiotensin receptor activation.

Summary
Biological activity
References

References
1. Noto NM, Restrepo YM, Pang HW, Stoyell-Conti F, West CA, Speth RC. (2023) Comparative evaluation of biased agonists Sarcosine¹ , d-Alanine⁸ -Angiotensin (Ang) II (SD Ang II) and Sarcosine¹ , Isoleucine⁸ -Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT₁ receptors. Pharmacol Res Perspect, 11 (1): e01053. DOI: 10.1002/prp2.1053 [PMID:36639940]

References

1. Noto NM, Restrepo YM, Pang HW, Stoyell-Conti F, West CA, Speth RC. (2023)
Comparative evaluation of biased agonists Sarcosine¹ , d-Alanine⁸ -Angiotensin (Ang) II (SD Ang II) and Sarcosine¹ , Isoleucine⁸ -Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT₁ receptors.
Pharmacol Res Perspect, 11 (1): e01053. DOI: 10.1002/prp2.1053 [PMID:36639940]