tetroxoprim   Click here for help

GtoPdb Ligand ID: 12328

Compound class: Synthetic organic
Comment: Tetroxoprim belongs to the diaminopyrimidine class of antibacterial compounds. Functionally, the compound is a selective inhibitor of bacterial dihydrofolate reductase (DHFR) [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 114.74
Molecular weight 334.16
XLogP 0.59
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES COCCOc1c(OC)cc(cc1OC)Cc1cnc(nc1N)N
Isomeric SMILES COCCOc1c(cc(cc1OC)Cc1cnc(nc1N)N)OC
InChI InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)
InChI Key WSWJIZXMAUYHOE-UHFFFAOYSA-N
References
1. Aschhoff HS, Vergin H. (1979)
Tetroxoprim--a new inhibitor of bacterial dihydrofolate reductase.
J Antimicrob Chemother, 5 (B): 19-25. [PMID:43863]
2. Bywater MJ, Holt HA, Reeves DS. (1979)
Activity in vitro of tetroxoprim-sulphadiazine.
J Antimicrob Chemother, 5 (B): 51-60. [PMID:536348]
3. Ferber H, Ahrens KH, Haase W. (1979)
A short-term study of tetroxoprim/sulphadiazine in the treatment of acute bronchitis and urinary tract infections.
J Antimicrob Chemother, 5 (B): 231-5. [PMID:395150]
4. Wiedemann B. (1979)
Activity of tetroxoprim and sulphadiazine alone and in combination on Gram-negative bacteria.
J Antimicrob Chemother, 5 (B): 45-7. [PMID:536347]