Synonyms: AVC® | sulphanilamide
sulfanilamide is an approved drug (FDA (1965))
Compound class:
Synthetic organic
Comment: Sulfanilamide is sulfonamide antimicrobial compound. It was first synthesized in 1908, but it was not until the 1930s that its antibacterial activity was discovered [3-4].
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References |
1. Achari A, Somers DO, Champness JN, Bryant PK, Rosemond J, Stammers DK. (1997)
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase. Nat Struct Biol, 4 (6): 490-7. [PMID:9187658] |
2. Bermingham A, Derrick JP. (2002)
The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays, 24 (7): 637-48. [PMID:12111724] |
3. Bickel MH. (1988)
The development of sulfonamides (1932-1938) as a focal point in the history of chemotherapy. Gesnerus, 45 Pt 1: 67-86. [PMID:3042521] |
4. Iyer HV. (2008)
History revisited-Prontosil red. J Emerg Med, 35 (2): 209-10. [PMID:18280088] |