ciproxifan

Ligand id: 1265

Name: ciproxifan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 54.98
Molecular weight 270.14
XLogP 2.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Cogé F, Guénin SP, Audinot V, Renouard-Try A, Beauverger P, Macia C, Ouvry C, Nagel N, Rique H, Boutin JA, Galizzi JP. (2001)
Genomic organization and characterization of splice variants of the human histamine H3 receptor.
Biochem J355: 279-288. [PMID:11284713]
2. Esbenshade TA, Fox GB, Krueger KM, Baranowski JL, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Pan JB, Faghih R, Bennani YL, Williams M, Hancock AA. (2004)
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Biochem Pharmacol68: 933-945. [PMID:15294456]
3. Esbenshade TA, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Fox GB, Faghih R, Bennani YL, Williams M, Hancock AA. (2003)
Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.
J Pharmacol Exp Ther305: 887-896. [PMID:12606603]
4. Ligneau X, Morisset S, Tardivel-Lacombe J, Gbahou F, Ganellin CR, Stark H, Schunack W, Schwartz JC, Arrang JM. (2000)
Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain.
Br J Pharmacol131: 1247-1250. [PMID:11090094]
5. Morisset S, Sasse A, Gbahou F, Héron A, Ligneau X, Tardivel-Lacombe J, Schwartz JC, Arrang JM. (2001)
The rat H3 receptor: gene organization and multiple isoforms.
Biochem Biophys Res Commun280: 75-80. [PMID:11162480]
6. Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, Liu WL, Stark H, Thurmond RL, Haas HL. (2015)
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
Pharmacol. Rev.67 (3): 601-55. [PMID:26084539]
7. Rouleau A, Héron A, Cochois V, Pillot C, Schwartz JC, Arrang JM. (2004)
Cloning and expression of the mouse histamine H3 receptor: evidence for multiple isoforms.
J Neurochem90: 1331-1338. [PMID:15341517]
8. Wulff BS, Hastrup S, Rimvall K. (2002)
Characteristics of recombinantly expressed rat and human histamine H3 receptors.
Eur J Pharmacol453: 33-41. [PMID:12393057]