durlobactam   Click here for help

GtoPdb Ligand ID: 12693

Synonyms: ETX-2514 | EXT2514 | Xacduro® (sulbactam and durlobactam)
Approved drug
durlobactam is an approved drug (FDA (2023))
Compound class: Synthetic organic
Comment: Durlobactam (ETX2514) is a broad-spectrum diazabicyclooctanone (DBO) class non-beta-lactam beta-lactamase inhibitor [1]. It reduces beta-lactamase-mediated degradation of beta-lactam antibacterials, and has been demonstrated to restore sulbactam activity against Acinetobacter species, including contemporary multidrug-resistant strains [4]. There is evidence that a few carbapenem- and colistin-resistant, metallo beta-lactamase (MBL)-producing strains of A. baumannii are resistant to sulbactam/durlobactam dual therapy [2,5].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 138.62
Molecular weight 277.26
XLogP -3.64
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC1=C[C@@H]2CN([C@@H]1C(=O)N)C(=O)N2OS(=O)(=O)O
Isomeric SMILES CC1=C[C@@H]2CN([C@@H]1C(=O)N)C(=O)N2OS(=O)(=O)O
InChI InChI=1S/C8H11N3O6S/c1-4-2-5-3-10(6(4)7(9)12)8(13)11(5)17-18(14,15)16/h2,5-6H,3H2,1H3,(H2,9,12)(H,14,15,16)/t5-,6+/m1/s1
InChI Key BISPBXFUKNXOQY-RITPCOANSA-N
References
1. Durand-Réville TF, Guler S, Comita-Prevoir J, Chen B, Bifulco N, Huynh H, Lahiri S, Shapiro AB, McLeod SM, Carter NM et al.. (2017)
ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
Nat Microbiol, 2: 17104. [PMID:28665414]
2. Findlay J, Poirel L, Bouvier M, Nordmann P. (2022)
In vitro activity of sulbactam-durlobactam against carbapenem-resistant Acinetobacter baumannii and mechanisms of resistance.
J Glob Antimicrob Resist, 30: 445-450. [PMID:35618210]
3. Kaye KS, Shorr AF, Wunderink RG, Du B, Poirier GE, Rana K, Miller A, Lewis D, O'Donnell J, Chen L et al.. (2023)
Efficacy and safety of sulbactam-durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii-calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK).
Lancet Infect Dis, 23 (9): 1072-1084. [PMID:37182534]
4. Papp-Wallace KM, McLeod SM, Miller AA. (2023)
Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species.
Clin Infect Dis, 76 (Supplement_2): S194-S201. [PMID:37125470]
5. Principe L, Di Bella S, Conti J, Perilli M, Piccirilli A, Mussini C, Decorti G. (2022)
Acinetobacter baumannii Resistance to Sulbactam/Durlobactam: A Systematic Review.
Antibiotics (Basel), 11 (12). DOI: 10.3390/antibiotics11121793 [PMID:36551450]