Synonyms: AZD-3229
Compound class:
Synthetic organic
Comment: AZD3229 is a lead dual KIT/PDGFRα inhibitor [1]. It was designed for potential to treat gastrointestinal stromal tumours driven by mutations in KIT or platelet-derived growth factor α (PDGFRα).
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References |
1. Banks E, Grondine M, Bhavsar D, Barry E, Kettle JG, Reddy VP, Brown C, Wang H, Mettetal JT, Collins T et al.. (2020)
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors. Sci Transl Med, 12 (541). [PMID:32350132] |