Synonyms: OBI3424 | TH-3424 | TH3424
Compound class:
Synthetic organic
Comment: OBI-3424 is a prodrug that is converted (activated) by aldo-keto reductase family 1 member C3 (AKR1C3) into an intermediary metabolite that spontaneously hydrolyses to generate a thiotepa-related DNA alkylating (cross-linking) agent [1]. It was designed as a chemotherapeutic agent, and has demonstrated efficacy in preclinical models of T-cell acute lymphoblastic leukemia (T-ALL).
|
References |
1. Evans K, Duan J, Pritchard T, Jones CD, McDermott L, Gu Z, Toscan CE, El-Zein N, Mayoh C, Erickson SW et al.. (2019)
OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL. Clin Cancer Res, 25 (14): 4493-4503. [PMID:31015346] |