Synonyms: compound 44 [PMID: 31525992] | EVER206 | SPR206
Compound class:
Synthetic organic
Comment: Upleganan (SPR206) is a polymyxin antibacterial with activity against multi-drug resistant (MDR) Gram-negative species, together with lower nephrotoxicity than polymyxin B [1].
|
|
References |
1. Brown P, Abbott E, Abdulle O, Boakes S, Coleman S, Divall N, Duperchy E, Moss S, Rivers D, Simonovic M et al.. (2019)
Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206. ACS Infect Dis, 5 (10): 1645-1656. [PMID:31525992] |
2. Bruss J, Lister T, Gupta VK, Stone E, Morelli L, Lei Y, Melnick D. (2021)
Single- and Multiple-Ascending-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Polymyxin Derivative SPR206. Antimicrob Agents Chemother, 65 (10): e0073921. [PMID:34339267] |
3. Rodvold KA, Bader J, Bruss JB, Hamed K. (2023)
Pharmacokinetics of SPR206 in Plasma, Pulmonary Epithelial Lining Fluid, and Alveolar Macrophages following Intravenous Administration to Healthy Adult Subjects. Antimicrob Agents Chemother, 67 (7): e0042623. [PMID:37338378] |
4. Zhang Y, Zhao C, Wang Q, Wang X, Chen H, Li H, Zhang F, Wang H. (2020)
Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. J Antimicrob Chemother, 75 (9): 2609-2615. [PMID:32591806] |