Ligand Id: 1298
Ligand name melanin-concentrating hormone
Species Human, Mouse, Rat

2D Structure

Summary Biological activity References Structure Similar ligands Radio analogues
References
1. Chambers, J., Ames, R. S., Bergsma, D., Muir, A., Fitzgerald, L. R., Hervieu, G., Dytko, G. M., Foley, J. J., Martin, J., Liu, W. S., Park, J., Ellis, C., Ganguly, S., Konchar, S., Cluderay, J., Leslie, R., Wilson, S. and Sarau, H. M. (1999)
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
Nature, 400: 261-265. [PMID:10421367]
2. Suply, T., Della Zuana, O., Audinot, V., Rodriguez, M., Beauverger, P., Duhault, J., Canet, E., Galizzi, J. P., Nahon, J. L., Levens, N. and Boutin, J. A. (2001)
SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.
J Pharmacol Exp Ther, 299: 137-146. [PMID:11561073]
3. Audinot, V., Lahaye, C., Suply, T., Beauverger, P., Rodriguez, M., Galizzi, J. P., Fauchere, J. L. and Boutin, J. A. (2001)
[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor.
Br J Pharmacol, 133: 371-378. [PMID:11375253]
4. Sailer, A. W., Sano, H., Zeng, Z., McDonald, T. P., Pan, J., Pong, S. S., Feighner, S. D., Tan, C. P., Fukami, T., Iwaasa, H., Hreniuk, D. L., Morin, N. R., Sadowski, S. J., Ito, M., Ito, M., Bansal, A., Ky, B., Figueroa, D. J., Jiang, Q., Austin, C. P., MacNeil, D. J., Ishihara, A., Ihara, M., Kanatani, A., Van der Ploeg, L. H., Howard, A. D. and Liu, Q. (2001)
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Proc Natl Acad Sci U S A, 98: 7564-7569. [PMID:11404457]
5. Hill, J., Duckworth, M., Murdock, P., Rennie, G., Sabido-David, C., Ames, R. S., Szekeres, P., Wilson, S., Bergsma, D. J., Gloger, I. S., Levy, D. S., Chambers, J. K. and Muir, A. I. (2001)
Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.
J Biol Chem, 276: 20125-20129. [PMID:11274220]

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