Synonyms: PBTZ169
Compound class:
Synthetic organic
Comment: Macozinone (PBTZ169) is the lead from a series of piperazine-containing benzothiazinones [1]. It has potent antimycobacterial activity and is under clinical evaluation as a treatment for tuberculosis (TB). Macozinone is an inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1].
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References |
1. Makarov V, Lechartier B, Zhang M, Neres J, van der Sar AM, Raadsen SA, Hartkoorn RC, Ryabova OB, Vocat A, Decosterd LA et al.. (2014)
Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med, 6 (3): 372-83. [PMID:24500695] |
2. Nguyen TQ, Hanh BTB, Jeon S, Heo BE, Park Y, Choudhary A, Moon C, Jang J. (2022)
Synergistic Effect of Q203 Combined with PBTZ169 against Mycobacterium tuberculosis. Antimicrob Agents Chemother, 66 (12): e0044822. [PMID:36321819] |