Synonyms: AZ-7371 | compound 1 [PMID:24957839] | TBA7371
Compound class:
Synthetic organic
Comment: TBA-7371 was identified in a lead optimization study of a series of 1,4-azaindoles, a novel class of antibacterial compounds [1-3]. It has potent antimycobacterial activity and is under clinical evaluation as a treatment for tuberculosis (TB). TBA-7371 is a non-covalent inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1].
|
|
References |
1. Chatterji M, Shandil R, Manjunatha MR, Solapure S, Ramachandran V, Kumar N, Saralaya R, Panduga V, Reddy J, Prabhakar KR et al.. (2014)
1,4-azaindole, a potential drug candidate for treatment of tuberculosis. Antimicrob Agents Chemother, 58 (9): 5325-31. [PMID:24957839] |
2. Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N et al.. (2013)
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo. J Med Chem, 56 (23): 9701-8. [PMID:24215368] |
3. Shirude PS, Shandil RK, Manjunatha MR, Sadler C, Panda M, Panduga V, Reddy J, Saralaya R, Nanduri R, Ambady A et al.. (2014)
Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem, 57 (13): 5728-37. [PMID:24874895] |