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Compound class:
Peptide or derivative
Comment: Kalata B1 is a cyclotide (plant-derived peptide with a head-to-tail cyclised backbone and a cystine knot core) produced in some plants (e.g. Carapichea ipecacuanha; source of ipecac root powder). Its structure confers stability against thermal and enzymatic degradation [1].
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| References |
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1. Colgrave ML, Craik DJ. (2004)
Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: the importance of the cyclic cystine knot. Biochemistry, 43 (20): 5965-75. [PMID:15147180] |
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2. Muratspahić E, Tomašević N, Nasrollahi-Shirazi S, Gattringer J, Emser FS, Freissmuth M, Gruber CW. (2021)
Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling. J Nat Prod, 84 (8): 2238-2248. [PMID:34308635] |
