Synonyms: EPI589
Compound class:
Synthetic organic
Comment: EPI-589 is a free-radical scavenger that was proposed to reduce cellular oxidative stress and mitochondrial dysfunction. The reduced form of EPI-589 is a substrate of NAD(P)H quinone oxidoreductases. EPI-589 is blood-brain barrier permeable and orally bioavailable.
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References |
1. Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N, Kanazawa Y, Matsumoto Y et al.. (2023)
An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study. JMIR Res Protoc, 12: e42032. [PMID:36716091] |
2. Noda N, Hamatani T, Shibue Y, Takagaki T, Kitamura A, Haranaka M, Ogama Y, Kakuyama H. (2022)
Phase 1 Study to Investigate the Safety, Tolerability, and Pharmacokinetics of EPI-589 in Healthy Participants. Clin Pharmacol Drug Dev, 11 (10): 1136-1146. [PMID:35988057] |