CPCCOEt

Ligand id: 1382

Name: CPCCOEt

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 68.12
Molecular weight 247.08
XLogP 1.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. (2003)
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
Mol Pharmacol.63: 1082-1093. [PMID:12695537]
2. Lavreysen H, Le Poul E, Van Gompel P, Dillen L, Leysen JE, Lesage AS. (2002)
Supersensitivity of human metabotropic glutamate 1a receptor signaling in L929sA cells.
Mol Pharmacol61: 1244-1254. [PMID:11961143]
3. Litschig S, Gasparini F, Rueegg D, Stoehr N, Flor PJ, Vranesic I, Prezeau L, Pin JP, Thomsen C, Kuhn R. (1999)
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.
Mol Pharmacol.55: 453-461. [PMID:10051528]