Ligand id: 1420

Name: ADX-47273

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 59.23
Molecular weight 369.13
XLogP 5.01
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP et al.. (2013)
In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.
Neuropharmacology, 64: 224-39. [PMID:22884720]
2. Le Poul E, Bessis AS, Lutgens R, Bonnet B, Rocher JP, Epping-Jordan M, Mutel V. (2005)
In vitro pharmacological characterisation of selective mGluR5 positive allosteric modulators.
Neuropharmacology, 49 (S1): 252-.