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Synonyms: GR 231118 | GR-231118 | GW 1229 | GW-1229 | GW1229
Compound class:
Peptide or derivative
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Dumont Y, Quirion R. (2000)
[(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol, 129 (1): 37-46. [PMID:10694200] |
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2. Dumont Y, Thakur M, Beck-Sickinger A, Fournier A, Quirion R. (2003)
Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY. Br J Pharmacol, 139 (7): 1360-8. [PMID:12890716] |
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3. Gehlert DR, Schober DA, Gackenheimer SL, Beavers L, Gadski R, Lundell I, Larhammar D. (1997)
[125I]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors. Peptides, 18 (3): 397-401. [PMID:9145427] |
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4. Tough IR, Holliday ND, Cox HM. (2006)
Y(4) receptors mediate the inhibitory responses of pancreatic polypeptide in human and mouse colon mucosa. J Pharmacol Exp Ther, 319 (1): 20-30. [PMID:16807358] |
