UDP N-acetyl-glucosamine

Ligand id: 1779

Name: UDP N-acetyl-glucosamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 18
Hydrogen bond donors 9
Rotatable bonds 11
Topological polar surface area 325.48
Molecular weight 607.08
XLogP -5.21
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Ashikov A, Routier F, Fuhlrott J, Helmus Y, Wild M, Gerardy-Schahn R, Bakker H. (2005)
The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine.
J. Biol. Chem., 280 (29): 27230-5. [PMID:15911612]
2. Freeman K, Tsui P, Moore D, Emson PC, Vawter L, Naheed S, Lane P, Bawagan H, Herrity N, Murphy K, Sarau HM, Ames RS, Wilson S, Livi GP, Chambers JK. (2001)
Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Genomics, 78: 124-128. [PMID:11735218]
3. Fricks IP, Carter RL, Lazarowski ER, Harden TK. (2009)
Gi-dependent cell signaling responses of the human P2Y14-receptor in model cell systems.
J Pharmacol Exp Ther,: -. [PMID:19339661]
4. Ishida N, Miura N, Yoshioka S, Kawakita M. (1996)
Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.
J. Biochem., 120 (6): 1074-8. [PMID:9010752]
5. Ishida N, Yoshioka S, Chiba Y, Takeuchi M, Kawakita M. (1999)
Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter.
J. Biochem., 126 (1): 68-77. [PMID:10393322]
6. Miura N, Ishida N, Hoshino M, Yamauchi M, Hara T, Ayusawa D, Kawakita M. (1996)
Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator.
J. Biochem., 120 (2): 236-41. [PMID:8889805]