Ligand Id: 1860
Ligand name apafant

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 100.85
Molecular weight 455.12
XLogP 3.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands Radio analogues
References
1. Parent, J. L., Gouill, C. L., Escher, E., Rola-Pleszczynski, M. and Stakova, J. (1996)
Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis.
J Biol Chem, 271: 23298-23303. [PMID:8798529]
2. Svetlov, S. and Nigam, S. (1993)
Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils.
Biochem Biophys Res Commun, 190: 162-166. [PMID:8380690]