apafant

Ligand id: 1860

Name: apafant

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 100.85
Molecular weight 455.12
XLogP 3.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Parent JL, Gouill CL, Escher E, Rola-Pleszczynski M, Stakova J. (1996)
Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis.
J Biol Chem271: 23298-23303. [PMID:8798529]
2. Svetlov S, Nigam S. (1993)
Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils.
Biochem Biophys Res Commun190: 162-166. [PMID:8380690]