Ligand id: 1952

Name: EP4A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 12
Topological polar surface area 123.41
Molecular weight 654.16
XLogP 9.97
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Machwate M, Harada S, Leu CT, Seedor G, Labelle M, Gallant M, Hutchins S, Lachance N, Sawyer N, Slipetz D, Metters KM, Rodan SB, Young R, Rodan GA. (2001)
Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).
Mol Pharmacol, 60: 36-41. [PMID:11408598]
2. Young RN, Billot X, Han Y, Slipetz DA, Chauret N, Belley M, Metters K, Mathieu MC, Greig GM, Denis D, Girard M. (2004)
Discovery and Synthesis of a Potent, Selective and Orally Bioavailable EP4 Receptor Agonist.
Heterocycles, 64 (1): 437-446.