Ligand id: 2324


Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 32.34
Molecular weight 230
XLogP 1.98
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M. (2005)
Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.
J. Biol. Chem., 280 (50): 41404-11. [PMID:16239218]
2. Singh S, Syme CA, Singh AK, Devor DC, Bridges RJ. (2001)
Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
J. Pharmacol. Exp. Ther., 296 (2): 600-11. [PMID:11160649]
3. Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V. (2007)
Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.
Curr. Med. Chem., 14 (13): 1437-57. [PMID:17584055]