NO | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

NO

GtoPdb Ligand ID: 2509

Synonyms: INOmax® | nitric oxide | nitrogen monoxide

NO is an approved drug (FDA (1999), EMA (2001))

Comment: Nitric oxide is a free radical and an important cellular signaling molecule involved in many physiological and pathological processes. The drugs nitroglycerin and amyl nitrite are nitric oxide precursors.

View more information in the IUPHAR Pharmacology Education Project: nitric oxide

References
1. Chen Y, Harry A, Li J, Smit MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. (1997) Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation. Proc Natl Acad Sci USA, 94 (25): 14100-4. [PMID:9391159]
2. Duprat F, Girard C, Jarretou G, Lazdunski M. (2005) Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species. J Physiol (Lond.), 562 (Pt 1): 235-44. [PMID:15513946]
3. Gao X, Sadana R, Dessauer CW, Patel TB. (2007) Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. J Biol Chem, 282 (1): 294-302. [PMID:17110384]
4. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001) Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Biochem Biophys Res Commun, 282 (1): 249-56. [PMID:11263999]
5. Hill J, Howlett A, Klein C. (2000) Nitric oxide selectively inhibits adenylyl cyclase isoforms 5 and 6. Cell Signal, 12 (4): 233-7. [PMID:10781930]
6. Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J, Homcy CJ. (1992) Isolation and characterization of a novel cardiac adenylylcyclase cDNA. J Biol Chem, 267 (19): 13553-7. [PMID:1618857]
7. Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y. (1995) Regulation of adenylyl cyclase by protein kinase A. J Biol Chem, 270 (21): 12481-4. [PMID:7759492]
8. Lai HL, Lin TH, Kao YY, Lin WJ, Hwang MJ, Chern Y. (1999) The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C. Mol Pharmacol, 56 (3): 644-50. [PMID:10462552]
9. Taussig R, Tang WJ, Hepler JR, Gilman AG. (1994) Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J Biol Chem, 269 (8): 6093-100. [PMID:8119955]
10. Yoshimura M, Cooper DM. (1992) Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci USA, 89 (15): 6716-20. [PMID:1379717]

References

1. Chen Y, Harry A, Li J, Smit MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. (1997)
Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation.
Proc Natl Acad Sci USA, 94 (25): 14100-4. [PMID:9391159]

2. Duprat F, Girard C, Jarretou G, Lazdunski M. (2005)
Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species.
J Physiol (Lond.), 562 (Pt 1): 235-44. [PMID:15513946]

3. Gao X, Sadana R, Dessauer CW, Patel TB. (2007)
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.
J Biol Chem, 282 (1): 294-302. [PMID:17110384]

4. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F. (2001)
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
Biochem Biophys Res Commun, 282 (1): 249-56. [PMID:11263999]

5. Hill J, Howlett A, Klein C. (2000)
Nitric oxide selectively inhibits adenylyl cyclase isoforms 5 and 6.
Cell Signal, 12 (4): 233-7. [PMID:10781930]

6. Ishikawa Y, Katsushika S, Chen L, Halnon NJ, Kawabe J, Homcy CJ. (1992)
Isolation and characterization of a novel cardiac adenylylcyclase cDNA.
J Biol Chem, 267 (19): 13553-7. [PMID:1618857]

7. Iwami G, Kawabe J, Ebina T, Cannon PJ, Homcy CJ, Ishikawa Y. (1995)
Regulation of adenylyl cyclase by protein kinase A.
J Biol Chem, 270 (21): 12481-4. [PMID:7759492]

8. Lai HL, Lin TH, Kao YY, Lin WJ, Hwang MJ, Chern Y. (1999)
The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C.
Mol Pharmacol, 56 (3): 644-50. [PMID:10462552]

9. Taussig R, Tang WJ, Hepler JR, Gilman AG. (1994)
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
J Biol Chem, 269 (8): 6093-100. [PMID:8119955]

10. Yoshimura M, Cooper DM. (1992)
Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.
Proc Natl Acad Sci USA, 89 (15): 6716-20. [PMID:1379717]