Ligand id: 2515

Name: [3H](-)devapamil    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 12
Topological polar surface area 54.72
Molecular weight 424.27
XLogP 5.37
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Goll A, Ferry DR, Striessnig J, Schober M, Glossmann H. (1984)
(-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle.
FEBS Lett., 176 (2): 371-7. [PMID:6092142]
2. Hagiwara M, Adachi-Akahane S, Nagao T. (1997)
High-affinity binding of DTZ323, a novel derivative of diltiazem, to rabbit skeletal muscle L-type Ca++ channels.
J. Pharmacol. Exp. Ther., 281 (1): 173-9. [PMID:9103495]
3. Nokin P, Clinet M, Beaufort P, Meysmans L, Laruel R, Chatelain P. (1990)
SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.
J. Pharmacol. Exp. Ther., 255 (2): 600-7. [PMID:2147036]
4. Zheng W, Rampe D, Triggle DJ. (1991)
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Mol. Pharmacol., 40 (5): 734-41. [PMID:1719369]