Ligand Id: 256
Ligand name SB 204070

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 74.02
Molecular weight 382.17
XLogP 2.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Van den Wyngaert, I., Gommeren, W., Verhasselt, P., Jurzak, M., Leysen, J., Luyten, W. and Bender, E. (1997)
Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
J Neurochem., 69: 1810-1819. [PMID:9349523]
2. Bender, E., Pindon, A., van Oers, I., Zhang, Y. B., Gommeren, W., Verhasselt, P., Jurzak, M., Leysen, J. and Luyten, W. (2000)
Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.
J Neurochem., 74: 478-489. [PMID:10646498]
3. Bonhaus, D. W., Berger, J., Adham, N., Branchek, T. A., Hsu, S. A., Loury, D. N., Leung, E., Wong, E. H., Clark, R. D. and Eglen, R. M. (1997)
[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors.
Neuropharmacology, 36: 671-679. [PMID:9225293]
4. Mialet, J., Berque-Bestel, I., Eftekhari, P., Gastineau, M., Giner, M., Dahmoune, Y., Donzeau-Gouge, P., Hoebeke, J., Langlois, M., Sicsic, S., Fischmeister, R. and Lezoualc'h, F. (2000)
Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines.
Br J Pharmacol, 129: 771-781. [PMID:10683202]
5. Mialet, J., Berque-Bestel, I., Sicsic, S., Langlois, M., Fischmeister, R. and Lezoualc'h, F. (2000)
Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells.
Br J Pharmacol, 131: 827-835. [PMID:11030734]