Ligand id: 260

Name: tropisetron

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 45.33
Molecular weight 284.15
XLogP 3.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Adham N, Gerald C, Schechter L, Vaysse P, Weinshank R, Branchek T. (1996)
[3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.
Eur J Pharmacol, 304: 231-235. [PMID:8813606]
2. Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO. (2001)
5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.
Naunyn Schmiedebergs Arch Pharmacol, 363: 146-160. [PMID:11218067]
3. Claeysen S, Sebben M, Journot L, Bockaert J, Dumuis A. (1996)
Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.
FEBS Lett, 398: 19-25. [PMID:8946946]
4. Lankiewicz S, Lobitz N, Wetzel CH, Rupprecht R, Gisselmann G, Hatt H. (1998)
Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig.
Mol. Pharmacol., 53 (2): 202-12. [PMID:9463477]
5. Maksay G, Laube B, Betz H. (1999)
Selective blocking effects of tropisetron and atropine on recombinant glycine receptors.
J. Neurochem., 73 (2): 802-6. [PMID:10428078]
6. Miyake A, Mochizuki S, Takemoto Y, Akuzawa S. (1995)
Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.
Mol. Pharmacol., 48 (3): 407-16. [PMID:7565620]
7. Supplisson S, Chesnoy-Marchais D. (2000)
Glycine receptor beta subunits play a critical role in potentiation of glycine responses by ICS-205,930.
Mol. Pharmacol., 58 (4): 763-70. [PMID:10999946]
8. Van den Wyngaert I, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W, Bender E. (1997)
Cloning and expression of a human serotonin 5-HT4 receptor cDNA.
J Neurochem., 69: 1810-1819. [PMID:9349523]
9. Yang Z, Ney A, Cromer BA, Ng HL, Parker MW, Lynch JW. (2007)
Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.
J. Neurochem., 100 (3): 758-69. [PMID:17181559]