Ligand id: 2668

Name: bezafibrate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 75.63
Molecular weight 361.11
XLogP 4.13
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Henke BR. (2004)
Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.
J. Med. Chem., 47 (17): 4118-27. [PMID:15293980]
2. Inoue I, Itoh F, Aoyagi S, Tazawa S, Kusama H, Akahane M, Mastunaga T, Hayashi K, Awata T, Komoda T, Katayama S. (2002)
Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.
Biochem. Biophys. Res. Commun., 290 (1): 131-9. [PMID:11779144]