Ligand id: 2715

Name: COOH

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 71.55
Molecular weight 429.19
XLogP 7.39
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Carley AN, Semeniuk LM, Shimoni Y, Aasum E, Larsen TS, Berger JP, Severson DL. (2004)
Treatment of type 2 diabetic db/db mice with a novel PPARgamma agonist improves cardiac metabolism but not contractile function.
Am. J. Physiol. Endocrinol. Metab., 286 (3): E449-55. [PMID:14600074]
2. Laplante M, Sell H, MacNaul KL, Richard D, Berger JP, Deshaies Y. (2003)
PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion.
Diabetes, 52 (2): 291-9. [PMID:12540599]