Ligand Id: 290
Ligand name McN-A-343

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 38.33
Molecular weight 281.11
XLogP 2.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
References
1. Richards, M. H. and Van Giersbergen, P. L. (1995)
Human muscarinic receptors expressed in A9L and CHO cells, activation by full and partial agonists.
Br. J. Pharmacol., 114: 1242-1249. [PMID:7620715]
2. Mei, L., Lai, J., Roeske, W. R., Fraser, C. M., Venter, J. C. and Yamamura, H. I. (1989)
Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.
J Pharmacol Exp Ther, 248: 661-670. [PMID:2537406]
3. Lambrecht, G., Moser, U., Grimm, U., Pfaff, O., Hermanni, U., Hildebrandt, C., Waelbroeck, M., Christophe, J. and Mutschler, E. (1993)
New functionally selective muscarinic agonists.
Life Sci, 52: 481-488. [PMID:7680092]