1-naphthylpiperazine

Ligand id: 3

Name: 1-naphthylpiperazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 15.27
Molecular weight 212.13
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Proc Natl Acad Sci U S A, 90: 408-412. [PMID:8380639]
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Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.
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Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
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Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors.
J Neurochem, 67: 2096-2103. [PMID:8863519]
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Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
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Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Mol Pharmacol, 43: 419-426. [PMID:8450835]
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[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
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Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1Dα and 5-HT1Dβ.
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