LGR7-truncate

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Ligands
LGR7-truncate

GtoPdb Ligand ID: 3893

Compound class: Peptide or derivative

Comment: A naturally occuring truncated form of the relaxin receptor 1 (RXFP1) [1-2]. This truncated form is uterus-specific and results from the deletion of exon-4. The exact amino acid sequence of this protein is unspecified in the reference

Summary
Biological activity
References

References
1. Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJ, Tregear GW, Bathgate RA. (2006) Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem, 281 (46): 34942-54. [PMID:16963451]
2. Scott DJ, Tregear GW, Bathgate RA. (2005) LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro. Ann N Y Acad Sci, 1041: 22-6. [PMID:15956683]

References

1. Scott DJ, Layfield S, Yan Y, Sudo S, Hsueh AJ, Tregear GW, Bathgate RA. (2006)
Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.
J Biol Chem, 281 (46): 34942-54. [PMID:16963451]

2. Scott DJ, Tregear GW, Bathgate RA. (2005)
LGR7-truncate is a splice variant of the relaxin receptor LGR7 and is a relaxin antagonist in vitro.
Ann N Y Acad Sci, 1041: 22-6. [PMID:15956683]