ambrisentan

Ligand id: 3951

Name: ambrisentan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 81.54
Molecular weight 378.16
XLogP 6.66
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Bolli MH, Marfurt J, Grisostomi C, Boss C, Binkert C, Hess P, Treiber A, Thorin E, Morrison K, Buchmann S et al.. (2004)
Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.
J. Med. Chem.47 (11): 2776-95. [PMID:15139756]